Partamol C

OTC

Indications

• For treatment of illness with pain or fever, such as headaches, influenza-like conditions, dental pain, muscular pain, menstrual period pain, in adult and in children weighing more than 25 kg (about 8 years of age).

Dosage

• Adults, children over 50 kg (about 15 years of age):
  1 – 2 effervescent tablets. Doses may be repeated up to every 4 hours, maximum 9 tablets daily.
• Children:
  Children 25 – 30 kg (about 8 – 10 years of age): 1 effervescent tablet. Doses may be repeated up to every 6 hours, maximum 5 tablets daily.
  Children 30 – 35 kg (about 10 – 12 years of age): 1 – 2 effervescent tablets. Doses may be repeated up to every 6 hours, maximum 6 tablets daily.
  Children 35 – 50 kg (about 12 – 15 years of age): 1 – 2 effervescent tablets. Doses may be repeated up to every 6 hours, maximum 7 tablets daily.

Usage

• Administered orally. The effervescent tablet is dissolved in a glass of water.

• Hypersensitivity to any of the ingredients.
• Large dose of vitamin C should be avoid in patients with:
  Glucose – 6 – phosphate dehydrogenase deficiency (risk of hemolytic anemia).
  History of nephrolithiasis, hyperoxaluria (increased risk of renal stone formation).
  Thalassemia (increased risk of iron absorption).

• Thrombocytopenia, leucopenia, pancytopenia, neutropenia and agranulocytosis;
• Nephropathy when abuse or prolonged excessive use of paracetamol;
• Asthma;
• Angioedema, eruptions.
• Hyperoxaluria, nausea, vomiting, heartburn, abdominal cramps, fatigue, flushing, headache, insomnia and sleepiness have been reported, diarrhoea.

• Paracetamol should be given with care to patients with impaired kidney or liver function. It should also be given with care to patient with alcohol dependence.
• Prolonged use of large doses of vitamin C may result in increased metabolism of the drug, scurvy may occur when intake of the vitamin is reduced to normal. Ingestion of large doses of the vitamin C during pregnancy has results in scurvy in neonates.
• Hemolysis has been associated with vitamin C administration in neonates with glucose-6-phosphate dehydrogenase deficiency and in otherwise healthy premature neonates.
• The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
• Partamol C contains aspartame. Aspartame is a source of phenylalanine. It may be harmful if you have phenylketonuria (PKU), a rare genetic disorder in which phenylalanine builds up because the body cannot remove it properly.
• Partamol C contains anhydrous sodium bicarbonate, anhydrous sodium carbonate, sodium benzoate, sodium saccharin; therefore, patients should have dietary sodium restriction.
• Partamol C contains tartrazine dye, which may cause allergic reactions.
• Paracetamol infrequent should remain the analgesic of choice in pregnancy. Use with caution in nursing women.
• Patients should be aware of how they react to drug before driving or operating machinery.