Paracetamol should be given with care to patients with impaired kidney or liver function. It should also be given with care to patient with alcohol dependence.
Prolonged use of large doses of vitamin C may result in increased metabolism of the drug, scurvy may occur when intake of the vitamin is reduced to normal. Ingestion of large doses of the vitamin C during pregnancy has results in scurvy in neonates.
Hemolysis has been associated with vitamin C administration in neonates with glucose-6-phosphate dehydrogenase deficiency and in otherwise healthy premature neonates.
The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
Partamol C contains aspartame. Aspartame is a source of phenylalanine. It may be harmful if you have phenylketonuria (PKU), a rare genetic disorder in which phenylalanine builds up because the body cannot remove it properly.
Partamol C contains anhydrous sodium bicarbonate, anhydrous sodium carbonate, sodium benzoate, sodium saccharin; therefore, patients should have dietary sodium restriction.
Partamol C contains tartrazine dye, which may cause allergic reactions.
Paracetamol infrequent should remain the analgesic of choice in pregnancy. Use with caution in nursing women.
Patients should be aware of how they react to drug before driving or operating machinery.