Partamol 500

OTC

Indications

• For treatment of mild to moderate pain and fever, especially in patients in whom salicylates are contraindicated or not tolerated.
• The drug is most effective in relieving low intensity pain of non-visceral origin.

Dosage

• Paracetamol should not be used for self-medication of pain for longer than 10 days in adults or 5 days in children, of marked fever (greater than 39.5^oC), fever persisting longer than 3 days, or recurrent fever.
• Adults and children >12 years of age:
  500 – 1000 mg every 4 – 6 hours as necessary, but should not exceed 4 g daily.
• Children 6 – 12 years of age:
  250 – 500 mg every 4 – 6 hours when necessary up to a maximum of 4 doses in 24 hours.

Usage

• Administered orally.

• Patients with anemia or cardiac, pulmonary, renal, or hepatic disease.
• Patients with alcohol dependence.
• Patients with known hypersensitivity to paracetamol or any of the excipients listed in.
• Patients with known glucose – 6 – phosphate dehydrogenase deficiency.

Uncommon

• Rash, nausea, vomiting,
• Blood dyscrasias (neutropenia, pancytopenia, leukopenia), anemia,
• Nephropathy, nephrotoxicity with chronic abuse.

• Paracetamol should be used with caution in patients with preexisting anemia, since cyanosis may not be apparent despite dangerously high blood concentrations of methemoglobin.
• Excessive intake of alcohol may increase the risk of paracetamol induced hepatotoxicity; avoid or limit alcohol intake.
• Caution is recommended when giving to patients with hepatic or renal impairment, susceptible individuals.
• The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
• Infrequent paracetamol should remain the analgesic of choice in pregnancy. Caution when use paracetamol for breastfeeding women.
• Patients should be aware of how they react to Partamol 500 before driving or operating machinery.