Partamol eff.

OTC

Indications

• For treatment of mild to moderate pain and fever, especially in patients in whom salicylates are contraindicated or not tolerated.
• The drug is most effective in relieving low intensity pain of non-visceral origin.

Dosage

• Paracetamol should not be used for self-medication of pain for longer than 10 days in adults and 5 days in children.
• Paracetamol should not be used for self-medication of marked fever (greater than 39.5^oC), fever persisting longer than 3 days, or recurrent fever.
• Adults and children ≥ 11 years of age: 1 tablet every 4 – 6 hours as necessary, not exceed 4 g daily.

Usage

• Partamol eff. is administered orally. The effervescent tablet is dissolved in a glass of water.

• Patients with known hypersensitivity to paracetamol or to any of the excipients listed in.
• Patients with severe hepatic impairment.

Uncommon

•  Skin rash and other allergic reactions occur occasionally, usually erythematosus or urticaria,
• Nausea, vomiting,
• Blood dyscrasias (neutropenia, pancytopenia, leukopenia), anemia,
• Nephropathy, nephrotoxicity with chronic abuse.

• Paracetamol should be used with caution in patients with preexisting anemia, since cyanosis may not be apparent despite dangerously high blood concentrations of methemoglobin.
• Excessive intake of alcohol may increase the risk of paracetamol induced hepatotoxicity; avoid or limit alcohol intake.
• Caution is recommended when giving to patients with hepatic or renal impairment, susceptible individuals.
• The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
• Partamol eff. contains aspartame. Aspartame is a source of phenylalanine. It may be harmful if you have phenylketonuria (PKU), a rare genetic disorder in which phenylalanine builds up because the body cannot remove it properly.
• Partamol eff. contains anhydrous sodium bicarbonate, anhydrous sodium carbonate, sodium benzoate, sodium saccharin; therefore, patients should have dietary sodium restriction.
• Paracetamol should be only used in pregnant women when clearly needed. Caution when use paracetamol for breastfeeding women.
• Patients should be aware of how they react to Partamol eff. before driving or operating machinery.