Partamol 325

OTC

Indications

For treatment of mild to moderate pain and fever, especially in patients in whom salicylates are contraindicated or not tolerated. The drug is most effective in relieving low intensity pain of non-visceral origin.

Dosage

• For analgesia or antipyrexia in adults or children older than 11 years, the usual oral of paracetamol is 325 – 650 mg every 4 – 6 hours as necessary, but should not exceed 4 g daily; higher single doses (e.g. 1 g) may be useful for analgesia in some patients.
• Paracetamol should not be used for self-medication of pain for longer than 10 days in adults or 5 days in children.
• Paracetamol should not be used for self-medication of marker fever (greater than 39.5°C), fever persisting longer 3 days, or recurrent fever.

Usage

Partamol 325 is administered orally.

• Patients with anemia or cardiac, pulmonary, renal, or hepatic disease.
• Patients with alcohol dependence.
• Patients with known hypersensitivity to paracetamol or to any of the excipients listed in.
• Patients with known glucose – 6 – phosphate dehydrogenase deficiency.

Uncommon

• Rash,
• Nausea, vomiting,
• Blood dyscrasias (neutropenia, pancytopenia, leukopenia), anemia,
• Nephropathy, nephrotoxicity with chronic abuse.

• Paracetamol should be used with caution in patients with preexisting anemia, since cyanosis may not be apparent despite dangerously high blood concentrations of methemoglobin.
• Excessive intake of alcohol may increase the risk of paracetamol induced hepatotoxicity; avoid or limit alcohol intake.
• Caution is recommended when giving to patients with hepatic or renal impairment.
• The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
• Infrequent paracetamol should remain the analgesic of choice in pregnancy. Caution when use paracetamol for breastfeeding women.
• Patients should be aware of how they react to Partamol 325 before driving or operating machinery.