Lostad T50

Lostad T50 contains losartan which blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland).

Pack size Box of 30 tablets, 100 tablets
Shelf-life 36 months
Composition Losartan Potassium
Dosage forms and strengths Film-coated tablet: 50 mg
Product code :



  • Hypertension, particularly in patients who develop cough with ACE inhibitors and to reduce the risk of stroke in patients with left ventricular hypertrophy.
  • Diabetic nephropathy (as serum creatinine is 3 – 3,0 mg/dl in patients ≤ 60 kg and 1.5 – 3,0 mg/dl in males > 60 kg and proteinuria).
  • Heart failure and in myocardial infarction.



Adults: 50 mg once daily. The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses.

Patients with intravascular fluid depletion, hepatic or renal impairment: An initial dose of 25 mg once daily.

Children ≥ 6 years: An initial dose of 0.7 mg/kg once daily, with a maximum of 50 mg, adjusted according to response.

Nephropathy in type 2 diabetic patients:

An initial dose of 50 mg once daily, increased to 100 mg once daily depending on the blood pressure.


Lostad T50 is administered orally.

Known hypersensitivity to any of the active substance or excipients.

Orthostatic hypotension. Insomnia, vertigo. Hyperkalaemia. Diarrhea, dyspepsia. Lightly decrease in Hb and hematocrit. Back/leg pain, muscular pain. Decrease in uric acid (when use with high dose of losartan). Cough (less likely than ACE inhibitors). Nasal congestion, sinusitis.

When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, losartan should be discontinued as soon as possible.

Because of the potential for adverse effects on the nursing infant, a decision should be made whether discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

When driving vehicles or operating machinery it must be borne in mind that dizziness or drowsiness may occasionally occur when taking antihypertensive therapy, in particular during initiation of treatment or when the dose increased.

Losartan should be used with caution in patients with renal artery stenosis.

The reduced doses may be required in patients with renal impairment and should be considered in patients with hepatic impairment.

Patients with volume depletion (for examples those who have received high-dose diuretic therapy) may experience hypotension; volume depletion should be corrected before starting therapy, or a low initial dose should be used.

Since hyperkalaemia may occur, serum-potassium concentrations should be monitored, especially in the elderly and patients with renal impairment, and the concomitant use of potassium-sparing diuretics should generally be avoided.

Lostad T50 contains lactose. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.