Hypertension: Irbesartan is used alone or in combination with other classes of antihypertensive agents in the management of hypertension.
Diabetic nephropathy: Irbesartan is used in the management of diabetic nephropathy manifested by elevated serum creatinine and proteinuria (urinary protein excretion exceeding 300 mg daily) in patients with type 2 diabetes mellitus and hypertension.
- Adult: The initial dosage is 300 mg once daily in patients without depletion of intravascular volume. If blood pressure response is inadequate with the initial dosage, dosage may be increased as tolerated to 300 mg once daily or a diuretic may be added. A dose of 75 mg once daily may be considered in elderly patients over 75 years, for patients with intravascular volume depletion, and for those receiving haemodialysis.
- Children 6 – 12 years of age or adolescents 13 – 16 years of age: An initial dosage is 75 or 300 mg once daily, respectively. If blood pressure response is inadequate, dosage may be increased to 150 or 300 mg once daily, respectively; higher dosages are not recommended.
Renal and hepatic impairment: The dosage adjustment is not necessary.
An initial dose of 75 mg once daily, increased to 300 mg once daily for maintenance.
Irbesartan STELLA 300 mg is administered orally and without regard to meals.