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Lostad T25
Rx

Lostad T25 contains losartan which blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues (e.g., vascular smooth muscle, adrenal gland).

Pack size Box of 30 tablets, 100 tablets
Shelf-life 36 months
Composition Losartan Potassium
Dosage forms and strengths Film-coated tablet: 25 mg
Product code :

PRESCRIBING INFORMATION

Indications:

  • Hypertension, particularly in patients who develop cough with ACE inhibitors and to reduce the risk of stroke in patients with left ventricular hypertrophy.
  • Diabetic nephropathy (as serum creatinine is 1.3 – 3.0 mg/dl in patients ≤ 60 kg and 1.5 – 3.0 mg/dl in males > 60 kg and proteinuria).
  • Heart failure and in myocardial infarction.

Dosage:

Hypertension:

Adults: 50 mg once daily. The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses.

Patients with intravascular fluid depletion, hepatic or renal impairment: An initial dose of 25 mg once daily.

Children ≥ 6 years: An initial dose of 0.7 mg/kg once daily, with a maximum of 50 mg, adjusted according to response.

Nephropathy in type 2 diabetic patients:

An initial dose of 50 mg once daily, increased to 100 mg once daily depending on the blood pressure.

Usage:

Lostad T25 is administered orally.

Known hypersensitivity to any of the active substance or excipients.

Orthostatic hypotension. Insomnia, vertigo. Hyperkalaemia. Diarrhea, dyspepsia. Lightly decrease in Hb and hematocrit. Back/leg pain, muscular pain. Decrease in uric acid (when use with high dose of losartan). Cough (less likely than ACE inhibitors). Nasal congestion, sinusitis.

Losartan should be used with caution in patients with renal artery stenosis, patients with volume depletion and the elderly.

Doses reduction may be required in patients with renal impairment and should be considered in patients with hepatic impairment.

When pregnancy is detected, losartan should be discontinued as soon as possible. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Patients should be aware of how they react to drug before driving or operating machinery.