Lostad T25

Rx

Indications

• Hypertension, particularly in patients who develop cough with ACE inhibitors and to reduce the risk of stroke in patients with left ventricular hypertrophy.
• Diabetic nephropathy (as serum creatinine is 1.3 – 3.0 mg/dl in patients ≤ 60 kg and 1.5 – 3.0 mg/dl in males > 60 kg and proteinuria).
• Heart failure and in myocardial infarction.

Dosage

Hypertension

• Adults: 50 mg once daily. The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses.
• Patients with intravascular fluid depletion, hepatic or renal impairment: An initial dose of 25 mg once daily.
• Children ≥ 6 years: An initial dose of 0.7 mg/kg once daily, with a maximum of 50 mg, adjusted according to response.

Nephropathy in type 2 diabetic patients

• An initial dose of 50 mg once daily, increased to 100 mg once daily depending on the blood pressure.

Usage

• Lostad T25 is administered orally.

• Known hypersensitivity to any of the ingredients.

• Orthostatic hypotension,
• Insomnia, vertigo,
• Hyperkalaemia,
• Diarrhea, dyspepsia,
• Lightly decrease in Hb and hematocrit,
• Back/leg pain, muscular pain,
• Decrease in uric acid (when use with high dose of losartan),
• Cough (less likely than ACE inhibitors). Nasal congestion, sinusitis.

• Losartan should be used with caution in patients with renal artery stenosis, patients with volume depletion and the elderly.
• Doses reduction may be required in patients with renal impairment and should be considered in patients with hepatic impairment.
• When pregnancy is detected, losartan should be discontinued as soon as possible. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
• Patients should be aware of how they react to drug before driving or operating machinery.