- Relief of acid-related dyspepsia.
- Treatment of gastro-oesophageal reflux disease (GORD).
- Management of peptic ulcer disease.
- Treatment of NSAID-associated ulceration.
- Zollinger-Ellison syndrome.
- Prophylaxis of acid aspiration during general anaesthesia.
Relief of acid-related dyspepsia: 10 or 20 mg daily for 2 to 4 weeks.
Gastro-oesophageal reflux disease (GORD):
+ The usual dose: 20 mg once daily for 4 weeks, followed by a further 4 to 8 weeks if not fully healed. In refractory oesophagitis, a dose of 40 mg daily may be used.
+ Maintenance therapy after healing of oesophagitis is 20 mg once daily, and for acid reflux is 10 mg daily.
Peptic ulcer disease:
+ A single daily dose of 20 mg, or 40 mg in severe cases. Treatment is continued for 4 weeks for duodenal ulcer and 8 weeks for gastric ulcer. Maintenance therapy: 10 to 20 mg once daily.
+ For the eradication of H. pylori in peptic ulceration: Omeprazole may be combined with antibacterials in dual or triple therapy. Dual therapy: Omeprazole 20 mg twice daily for two weeks. Triple therapy: Omeprazole 20 mg twice daily for one week.
NSAID-associated ulceration: 20 mg daily;
Zollinger-Ellison syndrome: 60 mg once daily, adjusted as required.
Prophylaxis of acid aspiration during general anaesthesia: 40 mg in the evening before surgery and a further 40 mg two to six hours before the procedure.
Dudencer is administered orally. It should be swallowed whole and not crushed or chewed.