- Treatment of infections caused by susceptible organisms; in lower respiratory tract infections including bronchitis and pneumonia, in oral and dental infections, in skin and soft tissue infections, in acute otitis media and in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis.
- Treatment of uncomplicated genital infections due to Chlamydia trachomatis. It is also indicated in the treatment of chancroid due to Haemophilus ducreyi and uncomplicated genital infections due to non-multiresistant Neisseria gonorrhoeae.
- Prophylaxis against Mycobacterium avium-intracellulare complex (MAC) infection or use in combination with ethambutol for the treatment of disseminated MAC (DMAC) infection in patients with advanced HIV infection.
Adults and children weighing > 45 kg
- Treatment of sexually transmitted diseases caused by
Chlamydia trachomatis and Haemophilus ducreyi: 1000 mg as a single oral dose.
Susceptible Neisseria gonorrhoeae: 1000 mg or 2000 mg of azithromycin + 250 mg or 500 mg ceftriaxone.
- In patients with advanced HIV infection:
Prophylaxis against MAC infections: 1200 mg once per week.
Treatment of DMAC infections: 600 mg once a day, in combination with other antimycobacterial agents against MAC.
- For all other indications:
The total dosage of 1500 mg should be given as 500 mg daily for 3 days or for 5 days with 500 mg given on the first day, then 250 mg daily from 2nd to 5th day.
- The maximum recommended total dose for any treatment is 1500 mg.
- For children weight > 45 kg: 3-day regimen: dose as per adults; 5-day regimen: dose as per adults.
- Azithromycin capsule should only be administered to children weighing more than 45 kg.
- The same dosage as in adult patients is used in the elderly. Elderly patients may be more susceptible to the development of torsades de pointes arrhythmia than younger patients.
In patients with renal impairment
- No dose adjustment is necessary in patients with mild to moderate renal impairment (GFR 10 – 80 ml/min). Caution should be exercised when azithromycin is administered to patients with severe renal impairment (GFR < 10 ml/min).
In patients with hepatic impairment
- The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment.
- Azicine should be given as a single daily dose. Azithromycin capsules can be taken with or without food.