Spirastad 3 M.I.U

Rx

Indications

• Infectious conditions in respiratory, cutaneous and genital tracts caused by sensitive organisms.
• Prophylaxis of meningitis caused by Meningococci in patients with contraindication to rifampicin.
• Prevention of congenital toxoplasmosis during pregnancy.
• Chemoprophylaxis of recurrent acute rheumatic arthritis in patients allergic to penicillins.

Dosage

Treatment of infectious conditions in respiratory, cutaneous and genital tracts; Chemoprophylaxis of recurrent acute rheumatic arthritis in patients allergic to penicillins

• Adults:
  5 million – 3 million IU daily, in 2 or 3 divided doses. Doses up to 15 million units have been given daily in divided doses for severe infections.
• Children ≥ 30 kg:
  150 thousand IU/kg daily, in 3 divided doses. Use other preparation for children < 30 kg.

Prophylaxis of meningitis due to Meningococci

• Adults:
  3 million IU every 12 hours for 5 days.
• Children ≥ 20 kg:
  75 thousand IU/kg every 12 hours for 5 days. Use other preparation for children < 20 kg.

Prevention of congenital toxoplasmosis during pregnancy

• 9 million IU daily in divided doses for 3 weeks, repeated 2-weekly intervals

Usage

• Spirastad 3 M.I.U is administered orally. Because food in the stomach reduces the bioavailability of spiramycin, the dose should be administered at least 2 hours before or 3 hours after a meal.

Patients with known hypersensitivity to spiramycin, erythromycin or to any of the ingredients.

Common

• Nausea, vomiting, diarrhea, indigestion;
• Vertigo, headache.

Uncommon

• Fatigue, epistaxis, sweating, heaviness in the chest;
• Acute colitis;
• Exanthema, urticarial.

• Spirastad 3 M.I.U must be discontinued if at the start of treatment, patients experience generalized erythema and pustules accompanied by fever. Any further administration of spiramycin alone or in combination is contraindicated.
• Spirastad 3 M.I.U should be used cautiously in patients with hepatic dysfunction, heart disease, arrhythmia (including people tend to prolong the QT interval); pregnant women.
• Mothers should discontinue breast feeding during spiramycin administration.
• Patients should be aware of how they react to drug before driving or operating machinery.