Tusstadt contains diphenhydramine that is an antihistamine of the ethanolamine type. It has significant sedative effects and also potent anti-cholinergic effects.

Pack size Box of 01 bottle of 60 ml, 100 ml
Shelf-life 36 months
Composition Diphenhydramine
Dosage forms and strengths Siro: 150 mg/ 60 ml; 250 mg/100 ml
Product code :



  • Symptomatic relief of allergic symptoms caused by histamine release which include nasal allergies and allergic dermatosis.
  • Can be used for mild nighttime sedation.
  • Prevention of motion sickness and as an antitussive.
  • Used as an antinauseant agent.
  • Treatment of phenothiazine induced dystonic reactions.


Adult and adolescent: Maximum dosage of 300 mg daily.

  • Antihistamineic: 25 to 50 mg every 4 to 6 hours as needed.
  • Antidyskinetic: For idiopathic and post encephalitic parkinsonism, 25 mg, 3 times daily, initially, the dose then being gradually increased to 50 mg, 4 times daily, if needed.
  • Antiemetic or anti-vertigo agent: 25 to 50 mg every 4 to 6 hours as needed.
  • Sedative-hypnotic: 50 mg, 20 to 30 minutes before bedtime, if needed.
  • Antitussive: 25 mg every 4 to 6 hours.


  • Antihistamineic:
    Children up to 6 years, 6.25 to 12.5 mg every 4 to 6 hours.
    Children 6 to 12 years, 12.5 to 25 mg every 4 to 6 hours, not to exceed 150 mg daily.
  • Antiemetic or anti-vertigo agent:
    1 to 1.5 mg/ kg every 4 to 6 hours as needed, not to exceed 300 mg daily.

Tusstadt is administered orally, it may be taken with food, water or milk to lessen gastric irritation.
When Tusstadt is used for prophylaxis of motion sickness, it shall be taken at least 30 minutes and preferably 1 to 2 hours, before exposure to conditions that may precipitate motion sickness.

  • Hypersensitivity to diphenhydramine and other antihistamines of similar chemical structure;
  • Patients with asthma;
  • Neonates.


  • Slight to moderate drowsiness, headache, fatigue, nervousness.
  • Thickening of bronchial secretions.
  • Nausea, vomiting, diarrhea, abdominal pain, xerostomia, appetite increase, weight gain, dry mucous membranes.

Less common

  • Hypotension, palpitations, edema.
  • Sedation, dizziness, paradoxical excitement, insomnia, depression.
  • Photosensitivity, rash, angioedema.
  • Urinary retention.
  • Hepatitis.
  • Myalgia, paresthesia, tremor.
  • Blurred vision.
  • Bronchospasm, epistaxis.
  • The sedative effect of Tusstadt can be much potentiated through concomitant intake of alcohol, or central nervous system inhibitory drugs.
  • Special caution should also be taken, and preferable Tusstadt should be avoided in patients with prostate hypertrophy, urinary bladder obstruction, or pyloroduodenal obstruction, due to the anticholinergic properties of the drug. Patients with myasthenia gravis or with narrow angle glaucoma should avoid taking Tusstadt.
  • Tusstadt should be used during pregnancy only when clearly needed. A decision should be made whether to discontinue nursing or diphenhydramine, taking into account the importance of the drug to the woman.
  • Avoid driving a motor vehicle or operating machinery while taking Tusstadt as its sedative effect.