Treatment with Stadloric 200 should be at the lowest effective daily dose for the shortest duration possible. The cardiovascular thrombotic risk has been observed most consistently at higher doses. Physicians should assess periodically appearance of cardiovascular adverse events, even in the absence of previous cardiovascular symptoms. Patients should be warned about the symptoms of serious cardiovascular events and seek physicians immediately if these symptoms occur.
Anti-platelet therapies should not be discontinued while using Stadloric 200.
Stadloric 200 should be used with caution in patients with: Hypertension; compromised cardiac function, pre-existing edema, or those taking diuretic treatment or otherwise at risk of hypovolemia; pre-existing congestive heart failure or hypertension; elderly, cardiovascular disease, using concomitant aspirin, glucocorticoids, or other NSAIDs, using alcohol or patients with a prior history of, or active, GI disease; dehydration; impaired renal/liver function, heart failure; systemic onset JIA.
Anticoagulation/INR should be monitored in patients taking a warfarin/coumarin type anticoagulant after initiating treatment with Stadloric 200 or changing the dose.
The concomitant use of Stadloric 200 and a non-aspirin NSAID should be avoided.
Stadloric 200 should be discontinued at the rst appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take Stadloric 200.
Consider withdrawal of NSAIDs, including celecoxib, in women who have difficulties conceiving or who are undergoing investigation of infertility. Celecoxib should be avoided during the third trimester of pregnancy. Celecoxib should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. A decision should be made whether to discontinue nursing or discontinue the drug.
Patients should be aware of how they react to drug before driving or operating machinery.