Calorie restriction may benefit healthy adults under 50

Calorie restriction is a type of diet that reduces calories without impacting nutrition. It can be achieved by eating less overall. Previous research has shown possible health benefits from long-term calorie restriction. Animal studies suggest that calorie restriction can delay progression of a number of age-related diseases.

Dr. William E. Kraus of Duke University led a team of researchers to investigate the health effects of calorie restriction in young and middle-aged adults who were not obese. The 2-year trial was supported by NIH’s National Institute on Aging (NIA) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

The investigators randomly assigned 218 adults to either calorie restriction or their usual eating pattern. At the beginning of the study, the men and women were healthy and either normal weight or slightly overweight. Those in the calorie restriction group were given coaching over the course of the trial to help them try to achieve and sustain a 25 percent reduction in their daily caloric intake.

The researchers tracked energy intake and expenditure. On average, the 143 adults in the calorie restriction group maintained nearly 12 percent calorie restriction over the entire 2-year period. This group also achieved an average reduction of 10 percent in body weight, mostly body fat. The 75 adults in the control group had stable calorie intake and weight during the study.

The team published a report in 2015 on the primary outcomes of the study, which were chosen to test whether calorie restriction would affect metabolism. They found that calorie restriction didn’t affect body temperature. It lowered the resting metabolic rate for a time, but the difference wasn’t significant at the end of 2 years.

In their new report, the researchers detailed outcomes related to risk factors for heart disease and diabetes. The findings were published on July 11, 2019, in Lancet Diabetes and Endocrinology.

Compared to the control group, calorie restriction substantially reduced waist measurements and blood pressure. Lab tests showed reduced LDL cholesterol and triglycerides. In addition, measures of inflammation, insulin resistance, glucose control, and metabolic syndrome greatly improved.

The findings suggest that modest calorie restriction may reduce the risk of heart disease and diabetes even in healthy adults who are not obese. “People can do this fairly easily by simply watching their little indiscretions here and there, or maybe reducing the amount of them, like not snacking after dinner,” Kraus says. More research is needed to understand how calorie restriction results in these benefits. The long-term impact of calorie restriction in healthy adults of normal weight also needs further study.

Source: National Institute on Aging


Stellapharm is one of leading generics pharmaceutical companies and strong producer of anti-viral drugs in Vietnam. The company established in Vietnam in 2000; and focuses on both prescription drugs and non-prescription especially in cardiovascular diseases, antiviral drugs, anti-diabetics drugs, etc. and our products are now used by millions of patients in more than 50 countries worldwide.

The company is globally recognized for its quality through our facilities have been audited and approved by stringent authority like EMA, PMDA, Taiwan GMP, local WHO and others.

Additional information for this article: Stellapharm J.V. Co., Ltd. – Branch 1
A: 40 Tu Do Avenue, Vietnam – Singapore Industrial Park, An Phu Ward, Thuan An City, Binh Duong Province, Vietnam
T: +84 274 376 7470 | F: +84 274 376 7469 | E: | W:

You May like

30 Nov 2022

Lão hóa miễn dịch và cách chống lại tình trạng này

Theo tuổi tác, hệ miễn dịch của chúng ta trở nên kém hiệu quả hơn trong việc đối phó với các tình trạng nhiễm trùng cũng như kém đáp ứng với việc chủng ngừa. Đồng thời, hệ miễn dịch lão hóa có mối liên hệ với tình trạng viêm mạn tính, từ đó làm tăng

30 Nov 2022


With age, the human immune system becomes less effective at tackling infections and less responsive to vaccinations. At the same time, the aging immune system is associated with chronic inflammation, which increases the risk of almost all conditions linked to old age. The good news is that exercising and adopting the right diet may help