Indications:
Adjunctive therapy in the treatment of partial seizures.
Treatment of peripheral neuropathic pain, pain after zoster.
Dosage:
Antiepileptic
Adults and children older than 12 years of age: 300 mg, once on the first day, twice on the second day, three times on the third day.
Thereafter, the dose can be further increased in 300 mg daily increments until reaching the effective dose, usually 900 – 1800 mg daily, given in three divided doses; the maximum dose is 2400 mg daily. The total daily dose should be taken in equally divided doses and the maximum dosage interval should not exceed 12 hours. Higher doses can be divided into 4 times daily.
Patients with renal impairment and undergoing hemodialysis:
- Clcr = 50 – 70 ml/min: 600 – 1200 mg daily, in 3 divided doses;
- Clcr = 30 – 49 ml/min: 300 – 600 mg daily, in 3 divided doses;
- Clcr = 15 – 29 ml/min: 300 mg daily, in 3 divided doses;
- Clcr < 15 ml/min: 300 mg on alternate days, in 3 divided doses;
- The loading dose is 300 – 400 mg for patients first use gabapentin, then 200 – 300 mg following each 4 hours of hemodialysis.
Children aged 6 to 12 years, weighing 30 – 36 kg: The three first days: 300 mg once daily; the normal dose and the maintenance dose: 300 mg, 3 times daily. Some children cannot tolerate add to daily, prolonged period of increase (up to weekly) may be more appropriate.
The treatment of peripheral neuropathic pain, pain after zoster
Adults: Maximum dose is 1800 mg daily, given in three divided doses. Or administered as 300 mg, once on the first day, twice on the second day, three times on the third day. Thereafter, the dose can be further increased in 300 mg daily, until dose increased up to a maximum of 1800 mg daily, given in three divided doses.
Elderly patients: Require dosage adjustment.
Usage:
Neuronstad is administered orally, the drug may be administered without regard to meals. Neuronstad is used as an adjunctive therapy in combination with other antiepilepsies. Gabapentin monotherapy may not be effective.