Misoclear

Rx

Indications:

• Reducing the risk of nonsteroidal anti-inflammatory agent-induced gastric ulcer.
• Short-term treatment of active duodenal ulcer and active benign gastric ulcer.
• Maintenance therapy following healing of gastric ulcer to reduce ulcer recurrence.
• Adjunct to mifepristone for the medical termination of intrauterine pregnancy according to the “National Guideline on reproductive health care services” issued together with the Minister of Health’s Decision No. 4128 / QD-BYT dated July 29, 2016.

Dosage:

Adults:

• Preventing ulcers caused by NSAIDs:

200 mcg 4 times daily, dosage may be reduced to 100 mcg 4 times daily in patients who do not tolerate the usual dosage.

• Stomach ulcer: Short-term treatment.

100 or 200 mcg 4 times daily for 8 weeks.

• Duodenal ulcer: Short-term treatment.

100 or 200 mcg 4 times daily or 400 mcg twice daily for 4 to 8 weeks.

• Support mifepristone in abortion:

In accordance with “National Guideline on reproductive health care services” issued together with Decision No. 4128 / QD-BYT dated July 29, 2016 of the Minister of Health.

Usage: 

Misoclear is administered orally. The incidence of misoprostol induced diarrhea may be minimized by using in divided doses after meals and at bedtime and by avoiding concomitantly use with a magnesium-containing or other laxative antacid..

Pregnant women and women planning a pregnancy.

Allergic to misoprostol or other prostaglandins or any component of the drug.

For indications for mifepristone support during pregnancy termination:

Absolute contraindications:

• Mitral valve stenosis, embolism and history of embolism.
• Adrenal gland disease.
• Blood coagulation disorders, using anticoagulants.
• Anemia (severe and moderate).
• Confirmed or suspected ectopic pregnancy.
• Pregnant at the old surgical wound in the uterus.
• Vegetable with comb teeth.

Relative contraindications:

• Long-term treatment with systemic steroids.
• Hypertension.
• Are acute genital tract infections.
• Genital deformities.
• Scarring of uterus with caution.

Diarrhea; abdominal pain, indigestion, flatulence, nausea and vomiting. Increased uterine spasms and abnormal vaginal bleeding (menorrhagia, intermenstrual bleeding); skin rash, headache, dizziness.

• Caution in patients with pre-existing cardiovascular disease, enteritis, patients prone to dehydration.
• The safety and efficacy of misoprostol in children under 18 years of age have not been established.
• Self-use of abortion pills can be life-threatening, please follow the instructions of the treating physician and National guidelines on reproductive health care services specified in Decision No. 4128/QD-BYT dated July 29, 2016 of the Minister of Health.
• Misoprostol should not be used by nursing women.
• Patients should be cautious when driving or operating machinery because misoprostol may cause dizziness.