Treatment of type 2 diabetes mellitus in adults. Metformin may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control.
Monotherapy and combination with other oral antidiabetic agents:
- Maximum recommended dose of 2 MR tablets per day with meal (if glycaemic control is not achieved: consider schedule one MR tablet x 2 times/day at the time of the morning and evening meals; if glycaemic control is still not achieved: switch to standard tablets to a maximum dose of 3000 mg daily);
- Currently treated with either 1000 mg or 2000 mg of metformin: maintain the daily dose of MR tablet equivalent to the current daily dose;
- Treated with a dose above 2000 mg metformin daily: not recommend switching to Metformin STELLA 1000 mg;
- New to metformin hydrochloride or transfer from another oral antidiabetic agent: initial 500 mg once daily (using other suitable preparation) with the evening meal, after 10 to 15 days, dosage is adjusted on the basis of blood glucose measurements.
Combination with insulin: initial 500 mg once daily (using other suitable preparation) with the evening meal, insulin dosage is adjusted on the basis of blood glucose measurements. After titration, consider switching to Metformin STELLA 1000 mg.
Metformin STELLA 1000 mg should not be used in children.
Elderly: doses adjustment bases on renal function.
Metformin STELLA 1000 mg is administered orally with or after meals.