- For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease.
- For reducing the volume of discharge from ileostomies, colostomies.
- Adults: initial dose is 4 mg followed by 2 mg after each unformed stool. Daily dosage should not exceed 16 mg. Clinical improvement is usually observed within 48 hours.
- Children: recommended first day dosage: 6 – 8 years (20 – 30 kg) 2 mg twice daily, 8 – 12 years (> 30 kg) 2 mg 3 times daily. Recommended subsequent daily dosage: 1 mg/10 kg only after a loose stool. Total daily dosage should not exceed recommended dosages for the first day.
- Adults: initial dose is 4 mg followed by 2 mg after each unformed stool until diarrhea is controlled, after which the dosage should be reduced to meet individual requirements. When the optimal daily dosage has been established, this amount may then be administered as a single dose or in divided doses.
- The daily maintenance dosage was 4 – 8 mg. A dosage of 16 mg was rarely exceeded. If clinical improvement is not observed after treatment with 16 mg per day for at least 10 days, symptoms are unlikely to be controlled by further administration. Loperamide administration may be continued if diarrhea cannot be adequately controlled with diet or specific treatment.
Drug is administered orally. Patients should receive appropriate fluid and electrolyte replacement as needed.