Beta – blockade may result in further depression of myocardial contractility and precipitate more severe failure.
At the first signs or symptoms of heart failure, discontinuation of bisoprolol should be considered.
Do not abrupt cessation of therapy with beta – blockers in patients with coronary artery disease and hyperthyroidism.
Beta – blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease.
Use with caution in patients with bronchospastic disease who do not respond to, or who cannot tolerate other antihypertensive treatment.
Beta – blockers may mask some of the manifestations of hypoglycemia, particularly tachycardia in patients subject to spontaneous hypoglycemia or diabetic patients receiving insulin or oral hypoglycemic agents.
Particular care should be taken when anesthetic, agents which depress myocardial function, are used.
Bisoprolol is not recommended for pregnancy and breastfeeding.
Patients should be aware of how they react to drug before driving or operating machinery (especially when starting treatment, dosage adjustment, alcohol drinking).