Treatment of hypertension, angina pectoris, cardiac dysrhythmia, and for early intervention in the acute phase of myocardial infarction.
Hypertension: The use initial adult oral dosage is 25 – 50 mg once daily. The full hypotensive effect may be seen after 1 to 2 weeks. Oral dosage may be increased to 100 mg once daily for optimum response.
Chronic stable angina pectoris: The initial adult oral dosage is 50 mg once daily. If an optimum response is not achieved within one week, oral dosage should be increased to 100 mg once daily.
Cardiac arrhythmias: Following control with intravenous atenolol, a suitable oral maintenance dosage is 50 – 100 mg daily, given as a single dose.
Early management of acute myocardial infarction:
Patients tolerating the total IV dose of 10 mg can receive 50 mg orally 10 minutes later and then 50 mg orally 12 hours later. Dosing is continued orally for 6 – 9 days at 100 mg daily given as a single daily dose or in 2 equally divided doses.
Patients with renal insufficiency:
The dose of atenolol should be reduced in patients with renal impairment, depending on the creatinine clearance (CC) as follows:
- CC 15 – 35 ml/minute per 1.73 m2: A maximum dosage of 50 mg daily is recommended.
- CC less than 15 ml/minute per 1.73 m2: 25 mg daily or 50 mg every other day.
- Dialysis patients: 25 – 50 mg orally after each dialysis.
Atenstad 50 is administered orally before meals.