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Argistad 250
Rx

Arginine is an essential amino acid in the urea cycle of patients with deficiency of the enzymes N-acetylglutamate synthase (NAGS), carbamyl phosphate synthetase (CPS), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS), or argininosuccinate lyase (ASL). Administration of arginine hydrochloride in patients with such disorders restores blood arginine concentrations and helps to prevent protein catabolism.

Pack size Box of 50 capsules, 60 capsules. Bottle of 100 capsules.
Shelf-life 24 months
Composition L-Arginine hydrochloride
Dosage forms and strengths Hard gelatin capsule: 250 mg
Product code :

PRESCRIBING INFORMATION

Indications:

  • Maintenance treatment for hyperammonemia in patients with deficiency of carbamoyl phosphate synthetase, ornithine transcarbamylase.
  • Maintenance treatment in patients with hyperammonemia, citrullinemia, argininosuccinic aciduria.
  • Support treatment of dyspepsia.
  • Support treatment to improve the exercising ability in patients with stable cardiovascular disease.
  • Nutritional supplementation for patients with urea cycle disorders such as hyperammonemia type I and II, citrullinemia, argininosuccinic aciduria and with deficiency of the enzymes N-acetylglutamate synthetase.

Dosage:

  • Maintenance treatment for hyperammonemia in patients with deficiency of carbamoyl phosphate synthetase, ornithine transcarbamylase in newborns and infants aged from 1–18 months: 100 mg/kg/day, divided into 3-4 times/day.
  • Maintenance treatment in patients with hyperammonemia, citrullinemia, argininosuccinic aciduria in newborns and infants aged from 1–18 months: 100-175 mg/kg once, taken 3-4 times/day with food. Adjust the dosage depending on the response.
  • Support treatment of dyspepsia in adults: 3-6 g/day
  • Support treatment to improve the exercising ability in patients with stable cardiovascular in adults: 6-21 g/day, each dose should not exceed 8 g.
  • Nutritional supplementation for patients with urea cycle disorder such as hyperammonemia type I and II, citrullinemia, argininosuccinic aciduria and with deficiency of the enzyme N-acetylglutamate synthetase in adults: 3-20 g/day depend on disease condition.

Usage:

Argistad 250 is administered orally.

Patients with known hypersensitivity to any ingredients in the formulation.

Patients with allergic tendencies.

Patients with urea cycle disorder who have arginase deficiency.

Abdominal pain and bloating, decreased platelet count and exacerbation of acrocyanosis, exacerbation of sickle cell anemia, and elevations of BUN and serum creatine and creatinine.

Allergic reaction, characterized by macular rash with redness and swelling of the hands and face that subsided rapidly foll.

  • Caution in patients with renal disease or anuria.
  • Caution in administration of high arginine dosages for acute hyperammonaemia.
  • The temporary effect of a high nitrogen load on the kidneys should be evaluated before the drug is used.
  • Arginine should not be used for treatment of hyperammonaemia caused by organic acidemias.
  • This drug should not be used during pregnancy. Caution should be exercised when arginine is to be administered to nursing women.
  • Patients should be aware of how they react to drug before driving or operating machinery.