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Argistad 1G
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Argistad 1G contains arginine which is an essential amino acid in the urea cycle of patients with deficiency of the enzymes NAGS, CPS, OTC, ASS or ASL. Administration of arginine hydrochloride in patients with such disorders restores blood arginine concentrations and helps to prevent protein catabolism.

Pack size Box of 20 ampoules x 5 ml. Box of 1 bottle x 125 ml
Shelf-life 24 months
Composition Arginine hydrochloride
Dosage forms and strengths Oral solution: 1 g/ 5 ml
Product code :

PRESCRIBING INFORMATION

Indications:

  • Maintenance treatment for hyperammonemia in patients with deficiency of carbamoylphosphate synthetase, ornithine transcarbamylase.
  • Maintenance treatment in patients with hyperammonemia, citrullinemia, argininosuccinic aciduria.
  • Support treatment of dyspepsia.
  • Support treatment to improve the exercising ability in patients with stable cardiovascular disease.
  • Nutritional supplementation for patients with urea cycle disorders such as: Hyperammonemia type I and II, citrullinemia, argininosuccinic aciduria and with deficiency of the enzymes N-acetylglutamate synthase.

Dosage:

  • Maintenance treatment for hyperammonemia in patients with deficiency of carbamoylphosphate synthetase, ornithine transcarbamylase: Newborns and infants aged from 1 – 18 months: 0.5 ml/kg/day, divided into 3 – 4 times/day.
  • Maintenance treatment in patients with hyperammonemia, citrullinemia, argininosuccinic aciduria: Newborns and infants aged from 1 – 18 months: 0.5-0.875 ml/kg/once, taken 3 – 4 times/day with food.
  • Support treatment of dyspepsia: Adults: 15-30 ml/day.
  • Support treatment to improve the exercising ability in patients with stable cardiovascular disease: Adults: 30 – 105 ml/day, each dose should not exceed 40 ml.
  • Nutritional supplementation for patients with urea cycle disorder such as: Hyperammonemia type I and II, citrullinemia, argininosuccinic aciduria and with deficiency of the enzymes N-acetylglutamate synthase: Adults: 15 – 100 ml/day, depend on disease condition.

Usage:

Argistad 1G is administered orally.

Patients with known hypersensitivity to any ingredients in the formulation.

Patients with allergic tendencies.

Patients with urea cycle disorder who have arginase deficiency.

Abdominal pain and bloating, decreased platelet count and exacerbation of acrocyanosis, exacerbation of sickle cell anemia, and elevations of BUN and serum creatine and creatinine.

Allergic reaction, characterized by macular rash with redness and swelling of the hands and face, that subsided rapidly following discontinuance of the drug and administration of diphenhydramine.

Precaution of sugar content (2 g per 5 ml) when prescribing for diabetic and low-sugar diet patients.

If diarrhoea occurs, should discontinue the drug. Arginine should be used cautiously in patients with renal disease or anuria.

When used for acute hyperammonaemia, administration of high arginine dosages may cause hyperchloremic metabolic acidosis; therefore, plasma chloride and bicarbonate concentrations should be monitored and simultaneous administration of appropriate amounts of bicarbonate may be required.

Arginine is ineffective for treatment of hyperammonaemia caused by organic acidemias.

This drug should not be used during pregnancy. Caution should be exercised when arginine is administered to nursing women.