Non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is the term for a range of conditions caused by a build-up of fat in the liver. It’s usually seen in people who are overweight or obese.

A healthy liver should contain little or no fat. It’s estimated up to 1 in every 3 people in the UK has early stages of NAFLD, where there are small amounts of fat in their liver.

Early-stage NAFLD does not usually cause any harm, but it can lead to serious liver damage, including cirrhosis, if it gets worse.

Having high levels of fat in your liver is also associated with an increased risk of serious health problems, such as diabetes, high blood pressure and kidney disease.

If you already have diabetes, NAFLD increases your chance of developing heart problems.

If detected and managed at an early stage, it’s possible to stop NAFLD getting worse and reduce the amount of fat in your liver.

Stages of NAFLD

NAFLD develops in 4 main stages.

Most people will only ever develop the first stage, usually without realising it.

In a small number of cases, it can progress and eventually lead to liver damage if not detected and managed.

The main stages of NAFLD are:

1. simple fatty liver (steatosis) – a largely harmless build-up of fat in the liver cells that may only be diagnosed during tests carried out for another reason
2. non-alcoholic steatohepatitis (NASH) – a more serious form of NAFLD, where the liver has become inflamed; this is estimated to affect up to 5% of the UK population
3. fibrosis – where persistent inflammation causes scar tissue around the liver and nearby blood vessels, but the liver is still able to function normally
4. cirrhosis – the most severe stage, occurring after years of inflammation, where the liver shrinks and becomes scarred and lumpy; this damage is permanent and can lead to liver failure (where your liver stops working properly) and liver cancer

It can take years for fibrosis or cirrhosis to develop. It’s important to make lifestyle changes to prevent the condition getting worse.

Am I at risk of NAFLD?

You’re at an increased risk of NAFLD if you:

• are obese or overweight – particularly if you have a lot of fat around your waist (an “apple-like” body shape)
• have type 2 diabetes
• have high blood pressure
• have high cholesterol
• have metabolic syndrome (a combination of diabetes, high blood pressure and obesity)
• are over the age of 50
• smoke

But NAFLD has been diagnosed in people without any of these risk factors, including young children.

Although it’s very similar to alcohol-related liver disease (ARLD), NAFLD is not caused by drinking too much alcohol.

Symptoms of NAFLD

There are not usually any symptoms of NAFLD in the early stages. You probably will not know you have it unless it’s diagnosed during tests carried out for another reason.

Occasionally, people with NASH or fibrosis (more advanced stages of NAFLD) may experience:

• a dull or aching pain in the top right of the tummy (over the lower right side of the ribs)
• extreme tiredness
• unexplained weight loss
• weakness

If cirrhosis (the most advanced stage) develops, you can get more severe symptoms, such as yellowing of the skin and the whites of the eyes (jaundice), itchy skin, and swelling in the legs, ankles, feet or tummy (oedema).

How NAFLD is diagnosed

NAFLD is often diagnosed after a blood test called a liver function test produces an abnormal result and other liver conditions, such as hepatitis, are ruled out.

But blood tests do not always pick up NAFLD.

The condition may also be spotted during an ultrasound scan of your tummy.

This is a type of scan where sound waves are used to create an image of the inside of your body.

If you’re diagnosed with NAFLD, further tests may be needed to determine which stage you have. This may involve a special blood test or having another type of ultrasound scan (Fibroscan).

Some people may also need a biopsy, where a small sample of liver tissue is taken using a needle so it can be analysed in a laboratory.

Children and young people with an increased risk of NAFLD (those with type 2 diabetes or metabolic syndrome) should have an ultrasound scan of their liver every 3 years.

Treatment for NAFLD

Most people with NAFLD will not develop any serious problems, but if you’re diagnosed with the condition it’s a good idea to take steps to stop it getting any worse.

There’s currently no specific medication for NAFLD, but making healthy lifestyle choices can help.

Treatment also may be recommended for associated conditions (high blood pressure, diabetes and cholesterol) or complications.

You may be advised to have regular appointments with your doctor to check your liver function and look for signs of any new problems.

Medicines

There’s not currently any medicine that can treat NAFLD, but various medicines can be useful in managing the problems associated with the condition.

For example, your doctor may recommend medicine to treat high blood pressure, treat high cholesterol, treat type 2 diabetes and treat obesity.

Liver transplant

If you develop severe cirrhosis and your liver stops working properly, you may need to be put on the waiting list for a liver transplant.

For adults, the average waiting time for a liver transplant is 135 days for transplants from recently deceased donors.

Or it may be possible to have a transplant using a section of liver removed from a living donor.

As the liver can regenerate itself, both the transplanted section and the remaining section of the donor’s liver are able to regrow to a normal size.

Things you can do if you have NAFLD

Adopting a healthy lifestyle is the main way of managing NAFLD.

For example, it can help to:

• lose weight – you should aim for a BMI of 18.5 to 24.9 (use the BMI calculator to work out your BMI); losing more than 10% of your weight can remove some fat from the liver and improve NASH if you have it
• eat a healthy diet – try to have a balanced diet high in fruits, vegetables, protein and carbohydrates, but low in fat, sugar and salt; eating smaller portions of food can help, too
• exercise regularly – aim to do at least 150 minutes of moderate-intensity activity, such as walking or cycling, a week; all types of exercise can help improve NAFLD, even if you do not lose weight
• stop smoking – if you smoke, stopping can help reduce your risk of problems such as heart attacks and strokes

NAFLD is not caused by alcohol, but drinking may make it worse. It’s therefore advisable to cut down or stop drinking alcohol.

Source: UK NATIONAL HEALTH SERVICE

About STELLA

Stellapharm is one of leading generics pharmaceutical companies and strong producer of anti-viral drugs in Vietnam. The company established in Vietnam in 2000; and focuses on both prescription drugs and non-prescription especially in cardiovascular diseases, antiviral drugs, anti-diabetics drugs, etc. and our products are now used by millions of patients in more than 50 countries worldwide.

The company is globally recognized for its quality through our facilities have been audited and approved by stringent authority like EMA, PMDA, Taiwan GMP, local WHO and others.

Additional information for this article: Stellapharm J.V. Co., Ltd. – Branch 1
A: 40 Tu Do Avenue, Vietnam – Singapore Industrial Park, An Phu Ward, Thuan An Town, Binh Duong Province, Vietnam
T: +84 274 376 7470 | F: +84 274 376 7469 | E: info@stellapharm.com | W: www.stellapharm.com