Used in the management of erectile dysfunction. Tadalafil is effective only in the presence of adequate sexual stimulation.
Usual dose: 10 mg at least 30 minutes before sexual intercourse. The daily dose may be increased to 20 mg or decreased to 5 mg, if necessary. Efficacy may persist for up to 36 hours after dosing. The maximum recommended dosing frequency is once daily and discourage continuous daily use.
Elderly patients: Dosage adjustments are not necessary.
Hepatic impairment mild to moderate: Maximum dose is 10 mg once daily; severe: Not recommended.
- ClCr = 31 – 50 ml/minute: Initial with 5 mg, once daily, and maximum dosage is 10 mg no more than once every 48 hours.
- ClCr < 30 ml/minute, including those undergoing hemodialysis: Maximum dosage is 5 mg, once daily.
In patients stabilized on alpha blocker therapy, a starting dose 5 mg may be used.
In patients taking potent inhibitors of the CYP3A4, the dose should not exceed 10 mg once every 72 hours.
Tadalafil STELLA 10 mg is administered orally once per day and without regard to meals.