Treatment of human immunodeficiency virus HIV-1 infected adult, adolescents and children 3 years of age and older. Post-exposure prophylaxis following occupational or non-occupational exposure to HIV.
Treatment of HIV infection
- Adults, adolescents and children ≥ 40 kg: 600 mg once daily; combined efavirenz with 2 other nucleoside (stavudine (d4T), lamivudine (3TC), efavirenz (EFV) or zidovudine (ZDV) + 3TC + EFV).
- Following occupational exposure to HIV: 600 mg once daily at bedtime in conjunction with 2 nucleoside reverse transcriptase inhibitors, started as soon as possible following occupational exposure (preferably within hours) and continued for 4 weeks.
- Following non-occupational exposure to HIV: 600 mg once daily at bedtime in conjunction with 2 other antiretrovirals, started as soon as possible following non-occupational exposure (preferably within 72 hours) and continued for 28 days.
- If efavirenz is coadministered with voriconazole, the voriconazole maintenance dose must be 400 mg every 12 hours and the efavirenz dose must be 300 mg once daily; when treatment with voriconazole is stopped, the initial dose of efavirenz should be restored.
- If efavirenz is coadministered with rifampicin to patients weighing 50 kg or more, the dose of efavirenz 800 mg/day may be considered.
- Efavirenz STELLA 600 mg is administered orally on an empty stomach. Avoid taking in a high fat meal (lipid). Dosing at bedtime is recommended during the first 2 to 4 weeks of therapy to improve tolerability and minimize the adverse events on central nervous system. If there are no adverse effects on the central nervous system, efavirenz can be taken at a convenient time of the day.
- The tablet should not be broken.
- Must take this drug on time, if you forget to take this drug on time, take it as soon as you remember. If the administration time is close to the next dose, skip the missed dose. Do not take a double dose at once.