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Sezstad 10
Rx

Ezetimibe, a cholesterol absorption inhibitor, is an antilipemic agent that differs chemically and pharmacologically from other currently available antilipemic agents.

Pack size Box of 10 tablets, 30 tablets, 60 tablets
Shelf-life 24 months
Composition Ezetimibe
Dosage forms and strengths Tablet: 10 mg
Product code :

PRESCRIBING INFORMATION

Indications

Ezetimibe is indicated as adjunctive therapy to diet in patients:

  • Primary hypercholesterolaemia (heterozygous familial and non-familial)
    Monotherapy: in patients in whom a statin is considered inappropriate or is not tolerated.
    Co-administered with an HMG-CoA reductase inhibitor (statin): in patients who are not appropriately controlled with a statin alone.
  • Homozygous familial hypercholesterolaemia: Co-administered with a statin.
  • Homozygous familial sitosterolaemia.

Dosage

  • The recommended dose is one tablet daily.
  • An appropriate lipid-lowering diet should continue during treatment.

Usage

  • Administered orally at any time of the day, with or without food.
  • Dosing of ezetimibe should occur either at least 2 hours before or 4 hours after administration of a bile acid sequestrant.
  • Known hypersensitivity to any of the ingredients.
  • Ezetimibe is not recommended for use in children below age 10.
  • Therapy with a statin is contraindicated during pregnancy and lactation, in active liver disease or unexplained persistent elevations in serum transaminases.
  • Headache,
  • Abdominal pain, diarrhea,
  • Rash, angioedema,
  • Fatigue,
  • Chest pain,
  • Arthralgia.
  • When ezetimibe is co-administered with a statin, liver function test should be performed at initiation of therapy and according to the recommendation of the statin.
  • If myopathy is suspected, drugs should be immediately discontinued.
  • Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
  • Ezetimibe should be given to pregnant women only if clearly necessary. Ezetimibe should not be used during lactation.
  • Patients should be aware of how they react to drug before driving or operating machinery.