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Acyclovir STADA 200 mg | 400 mg | 800 mg
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Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against Herpes simplex virus types 1 (HSV-1), 2 (HSV-2) and Varicella zoster virus (VZV).

Pack size Acyclovir STADA 200 mg: Box of 25 tablets, 50 tablets | Acyclovir STADA 400 mg: Box of 35 tablets, 50 tablets | Acyclovir STADA 200 mg: Box of 35 tablets, 50 tablets.
Shelf-life 48 months
Composition Acyclovir
Dosage forms and strengths Tablet. 200 mg/ 400 mg/ 800 mg
Product code :

PRESCRIBING INFORMATION

Treatment of Herpes simplex virus (HSV) infections

  • Treatment of initial and recurrent Herpes simplex virus infection (type 1 and 2) in mucosa – skin (stomatitis, genital inflammation), in eye (keratitis).
  • Prophylaxis of HSV infection in mucosa – skin when recurrences occur at least 6 times a year, in eyes (recurrent keratitis occur after twice a year) or in eye surgery.

Treatment of Varicella zoster virus infection (VZV)

  • Herpes zoster, prophylaxis of complications in eye due to zoster in eye.
  • Chickenpox in patients more than 2 years of age.

Dosage:

Treatment of Herpes simplex virus (HSV) infections

  • Treatment of primary HSV infections: 200 mg five times daily (usually every 4 hours while awake) for 5 – 10 days; patients with keratitis: 400 mg x 5 times/day in 10 days, severely immunocompromised patients or those with impaired absorption: 400 mg five times daily for 5 days, patients with renal impairment (ClCr < 10 mL/min): 200 mg every 12 hours, children aged under 2 years: half the adult dose.
  • Suppression of recurrent HSV infections: 800 mg daily in 2 – 4 divided doses (dosage can be reduced to 400 – 600 mg daily, higher doses of 1 gram daily have also been used); HSV infection in eyes (& eye surgery): 800 mg/day in 2 divided doses; reassessment should be performed after 6 – 12 months of treatment.
  • Prophylaxis of HSV: 200 – 400 mg four times daily (children aged under 2 years: half the adult dose).
  • Chronic suppressive treatment: a dose of 200 mg five times daily for 5 days has been recommended, preferably initiated during the prodromal period.

Treatment of Varicella zoster virus (VZV) infections

  • Chickenpox: 800 mg four or five times daily for 5 to 7 days; patients with renal impairment have creatinine clearance (ClCr) < 10 mL/min: 800 mg every 12 hours, ClCr 10-25 mL/min: 800 mg three times a day every 8 hours, children (≥ 6 years old: 800 mg, 2 – 5 years old: 400 mg, < 2 years old: 200 mg): four times daily, continue for five days.
  • Shingles: adults and children > 2 years old: 800 mg five times daily may be given for 7 to 10 days.

Patients with renal impairment associated with HIV experienced hemodialysis: 200-800 mg every 6-8 hours (ClCr 50-80mL/min), every 8-12 hours (ClCr 25-50mL/min), every 12-24 hours (ClCr 10-25mL/min); 200-400 mg every 24 hours (ClCr < 10mL/min); add 1 dose immediately after hemodialysis.

Usage:

Stacyvir is orally taken.

Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

  • Renal impairment is usually reversible and may progress to acute renal failure.
  • Increased serum bilirubin and liver enzymes, haematological changes, skin rashes (including erythema multiform, Stevens -Johnson syndrome and toxic epidermal necrolysis), fever, headache, dizziness and gastrointestinal effects such as nausea, vomiting and diarrhoea. Anaphylaxis. Hepatitis and jaundice have been reported rarely.
  • Elderly patients and patients with renal impairment are at increased risk of developing neurological side effects and should be closely monitored for evidence of these effects. These reactions were generally reversible on discontinuation of treatment.
  • Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Acyclovir should be administered to a nursing mother with caution and only when indicated.
  • Patients should be aware of how they react to drug before driving or operating machinery.