Indications:
- Vertigo
- Elderly suffering from memory impairment, vertigo, a lack of concentration or of alertness, changes of mood, a deterioration in behaviour and personal negligence, the dementia produced by multiple cerebral infarcts.
- Chronic alcoholism.
- Sickle-cell anemia.
- Myoclonus of cortical origin.
Dosage:
The total daily dose: 30 – 160 mg/kg/day. This is administered twice daily, but may also be given in 3 or 4 separate doses.
As a long-term therapy for psycho-organic syndrome in the elderly: 2 – 2.4 g daily. The loading dose can be as high as 4.8 g/day during the initial weeks of treatment.
Sickle-cell anemia: 160 mg/kg/day divided in 4 equal doses.
Alcoholism: 12 g daily during the initial withdrawal period. Subsequent maintenance therapy: Oral daily dose of 2.4 g.
Cognitive deficits resulting from head injury, whether or not these are associated with vertigo: the initial dose can vary from 9 – 12 g daily. Maintenance therapy thereafter is a daily oral dose of 2.4 g, given for a period of not less than 3 weeks.
In cortical myoclonus: Doses of 7.2 g are given daily increasing by 4.8 g daily every 3 or 4 days up to a maximum of 20 g daily. It is given in 2 or 3 divided doses. Attempts should be made to reduce the dose of other drugs. Children under 16 years are not recommended.
Renal impairment: Dosage should be reduced:
- CC between 50 and 79 ml/minute: 2/3 of the usual dose, given in 2 or 3 divided doses.
- CC between 30 and 49 ml/minute: 1/3 of the usual dose, given in 2 divided doses.
- CC between 20 and 29 ml/minute: 1/6 of the usual dose, given as a single dose.
- CC less than 20 ml/minute: Contraindicated.
Usage:
Pracetam 1200 is administered orally.
