Perindastad 4

Perindopril is an inhibitor of the enzyme that converts angiotensin I into angiotensin II (ACE), acts through its active metabolite, perindoprilat.

Pack size Box of 30 tablets
Shelf-life 36 months
Composition Perindopril Erbumine
Dosage forms and strengths Tablet: 4 mg.
Product code :



Hypertension. Symptomatic heart failure. Reduction of risk of cardiac events in patients with a history of myocardial infarction and/or revascularization.


  • Hypertension: Perindopril may be used in monotherapy or in combination with other classes of antihypertensive therapy. Commence with 4 mg, may be increased to 8 mg once daily after one month. Elderly patients commence with 2 which may be progressively increased to 4 mg after one month then to 8 mg if necessary depending on renal function.
  • Symptomatic heart failure: Start with 2 mg, may be increased by increments of 2 mg at intervals of no less than 2 weeks to 4 mg once daily if tolerated.
  • Stable coronary artery disease: Start with 4 mg once daily for two weeks, then increased to 8 mg once daily, depending on renal function and provided that 4 mg dose is well tolerated. Elderly patients should receive 2 mg once daily for one week, then 4 mg once daily the next week, before increasing the dose up to 8 mg once daily depending on renal function. Patients with renal impairment: ClCr 30-60 ml/min: 2 mg/day; ClCr 15 – 30 ml/min: 2 mg, every other day; haemodialysed patients (dialysis clearance of perindoprilat is 70 ml/min, the dose should be taken after dialysis) and ClCr < 15 ml/min: 2 mg on the day of dialysis.


It is taken once daily in the morning before a meal.

Known hypersensitive to any of the active substance or excipients.

History of angioedema related to previous ACE inhibitors treatment.

Hereditary or idiopathic angioedema.

The concomitant use of perindopril with aliskiren containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/ 1.73 m2).

Pregnancy and lactation.

Headache, disorders of mood and/or sleep disorders, asthenia, blood pressure not sufficiently controlled at the start of treatment; Non-specific GI disorders, taste alteration, vertigo, cramp; Urticaria; Dry cough, irritative type.

  • Patients with volume or salt restriction, prolonged diuretic therapy, dialysis, diarrhea, or vomiting, congestive heart failure.
  • Patients with unilateral or bilateral renal artery stenosis, preexisting renal impairment, or concomitant diuretic therapy.
  • Patients with renal impairment, diabetes mellitus, those receiving drugs that can increase serum potassium concentration.
  • Patients undergoing surgery or during anesthesia with agents that produce hypotension.
  • Patients should be aware of how they react to drug before driving or operating machinery.